Acd is a delayed hypersensitivity reaction that is diagnosed by an epicutaneous patch test. Allergic contact dermatitis from paraben is low, ranging from 0 to 4. Patch testing to a steroid cream with low paraben concentrations may give a false. Two cases of allergic contact dermatitis acd to parabens are used to discuss the background of. Allergen number showing its position on the panel is shown in brackets. Two cases of allergic contact dermatitis acd to parabens are used to discuss the background of parabens, their allergenicity, patch testing issues, and several paraben paradoxes. The allergic reactions usually appear 2 to 4 days after applying the.
Sensitized individuals may be able to use products containing parabens on non. This includes allergy to hair dye, shoes, active ingredients, preservative and fragrances in sunscreens, cosmetics and medicaments. Contact allergy to paraaminobenzoic acid paba and derivatives is not uncommon in dermatology practice. It is important that you familiarize yourself with this chemical and take steps to. The north american contact dermatitis group reports allergenicity ranging from 0. The patch test relies on diffusion of very tiny haptenallergens see below getting into the skin, where they are captured by antigen recognition cells dentritic cells.
Topical corticosteroids those not containing paraben preservatives emollients. Patch testing with 15% paraben mix in petrolatum is used. Get a printable copy pdf file of the complete article 475k, or click on a page image below to browse page by page. Typical symptoms include redness, swelling, itching, and fluidfilled blisters. In general, individuals with positive patch test reactions to parabens should not routinely avoid. Mi was initially used occupationally, in paints, adhesivesglues and cleaners etc, as a mixture with methylchloroisothiazolinone mci.
This contact allergy may cause your skin to react when it is exposed to this substance although it may take several days for the symptoms to appear. Review by germanys paulehrlichinstitute pei is an ongoing process. An overview of parabens and allergic contact dermatitis. Paraben mix contains the following five substances. All allergeaze allergens are manufactured by a gmpcertified pharmaceutical company in accordance with guidelines on good manufacturing practices gmp and good laboratory practices glp. Patch tests to the offending steroid creams or bases with their lower paraben concentrations may give false negative reactions. Treatment of contact dermatitis due to parabens exposure. Most cases of paraben contact allergy are caused by topical creams applied to leg ulcers or chronic dermatoses. Parabens have been under scrutiny for some time with the very limited reports of parabeninduced allergic contact dermatitis.
The photos of paraben allergy below are not recommended for people with a weak psyche. The optimum patch test concentration for detecting this sensitivity is 5% paraben in petrolatum. Brief or occasional contact may not pose a problem. Parabens are widely used as preservatives in cosmetics and pharmaceuticals, as well. Although acd to parabens has been reported, given the widespread use, it is relatively uncommon. Fragrance contact allergen of 2007 standard fragrance mix. Diagnostic patch testing is an investigation undertaken on patients with a history of dermatitis eczema in order to determine whether they have a contact allergy and then evaluate the relation if any of the contact allergy to their dermatitis see section final evaluation. Methylparabenan overlooked cause of local anesthetic. Paraben mix mx03c your patch testing results indicate that you have a contact allergy to paraben mix. Propyl paraben propyl4hydroxybenzoate p020 your patch testing results indicate that you have a contact allergy to propyl paraben. Visit for more information about contact allergies and patch testing your t.
The goal is for physicians to both add and search for information regarding specific allergens and topics. Methylparaben and propylparaben have been classified as generally recognized as safe in foods by the us food and drug administration. Founded in 1989, the mission of the american contact dermatitis society acds is to be the premier organization cultivating advancements in the diagnosis and care of dermatitis through the promotion of education, research, and advocacy. Allergic contact dermatitis facts archives dermatitis. Phototoxic dermatitis occurs when the allergen or irritant is activated by sunlight. The first case of paraben contact allergy was reported in 1940 by bonnevie 30.
Links to pubmed are also available for selected references. Your patch testing results indicate that you have a contact allergy to paraben mix. Positive patch test ppt reactions to paraben mix were reported at 1. This phenomenon is referred to as the paraben paradox, which hypothesizes that 1 patients who are sensitive to parabens often have falsenegative patch test reactions when the parabens are patchtested on healthy skin, and 2 paraben patch test positive patients may be nonreactive when using parabencontaining products on normal intact skin, but may develop dermatitis when these same products are applied to damaged skin. Full text full text is available as a scanned copy of the original print version. In the last 12 years, 67 patients showed positive patch tests to paba or isobutyl paba.
Patch testing for allergic contact dermatitis in the. Selftesting a product for parabens is possible but should be done only after first talking with your doctor. Allergen database contact dermatitis institute leaders. Systemic contact dermatitis caused by ingestion of parabens is rare. The possibility of unrecognized paraben sensitivity as the cause of a protracted contact dermatitis should be considered. Paraben stability in sewage sludge is relatively high due to their ability to bind with organic matter. Allergic contact dermatitis acd is affecting 80 million people in the usa. Predictive patch testing with parabencontaining cosmetics has yielded no cases of allergic dermatitis, whereas there is a larger number roughly 1% among patients undergoing patch testing for suspected allergic contact dermatitis the paradox questioned in this scenario is how, with the extensive testing performed, this could occur 245. It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it.
Once the dermatitis appears on the skin, treatment is as for any acute dermatitis eczema. Paraben mix in contact with your skin may result in dermatitis. Typical symptoms include redness, swelling, itching and fluidfilled blisters. We wish you a cure and never get sick of this disease. The author details the different chemical substances that can be included in these pastes, usual and unusual. Our society is dedicated to understanding, and investigating the interplay among, contact, occupational. Test results indicate that you have a contact allergy to carba mix. Anyone diagnosed with paraben mix allergy should avoid exposure to parabencontaining products. This contact allergy may cause your skin to react when it is exposed to this substance, although it may take several days for the symptoms to appear. Test results indicate that you have a contact allergy to paraben mix. Individuals allergic to parabens often experience reactions to these ingredients only on inflamed skin and may tolerate products which contain these ingredients. Diagnosis of allergic contact dermatitis can often be supported by patch testing. Mowad parabens, methyl, ethyl, propyl, benzyl, and butyl, are the most common preservatives in use today.
Paraben mix b allergic contact dermatitis database. Strongly positive patch test reactions in four patients with marked paraben allergy correlated well with the clinical course. Soil adsorption coefficient values were calculated by the u. Parabens a common allergen with lots of hype and no real. Patch testing is used to detect allergic contact dermatitis type iv hypersensitivity reaction.
Since 2005, it has been widely used in cosmetics and household products, such as moist wipes, shampoos, cleaners and liquid laundry products. However, paraben allergy may be becoming more common, as it was reported in the 20032004 nacdg data to be at least 1. This contact allergy may cause your skin to react when it is exposed to this. Contact dermatitis is a type of inflammation of the skin it results from either exposure to allergens allergic contact dermatitis or irritants irritant contact dermatitis. When patch tested, a paraben mix is typically used to screen for contact allergy, combining 4 or 5 individual parabens at varying concentrations. According to a 2015 study by warshaw et al, parabens caused anywhere from 1. Paraben mix allergy is diagnosed from the clinical history and by performing special allergy tests, i. Patient information paraben mix amazon web services. Parabens common contact allergens wiley online library. Exposure to parabens can cause your skin to become dry, itchy and swollen. Paraben mix allergy is diagnosed from the clinical history and by performing patch tests. Authoritative facts about the skin from dermnet new zealand.
The contact dermatitis institute allergen database was designed as a wikilike resource for information regarding allergic contact dermatitis. The contact allergy to toothpastes is a subject that is not sufficiently studied. Announcing the contact dermatitis awareness ribbon on march 19, 2016 a montessori teacher and a customer service representative, two mothers with children suffering with allergic contact dermatitis, joined together to start a patientcentered outreach group on facebook called eczema, contact dermatitis and patch testing alliance. Repeat exposure to skin, particularly damaged skin, but parabens can trigger an allergic reaction called contact dermatitis. Sensitization may occur via paba itself or related parasubstituted compounds crossreacting with paba. European society of contact dermatitis guideline for. The contact allergen database provides information to the more common causes of allergic contact dermatitis.
Many of the allergeaze allergens have already been licensed by pei, while remaining. To search for an allergen or topic, simply click on the alphabetical bar at the top of the. Systemic contact dermatitis is a controversial condition with a nonspecific generalised dermatitis and blistering of the hands. It affects mainly females with allergy to nickel on patch testing and the dermatitis is presumably nickelinduced id reaction. This website was created for individuals to better understand their specific allergens and how to avoid them, especially after a skin patch test. Testing for paraben allergen can be done by patch testing. The 2019 nonallergen of the year mdedge dermatology.